Glyfoline
WebGlyfoline exhibits cytotoxic activity in vitro and antitumor activity in mice bearing murine or human solid tumors, but the underlying mechanisms are unknown. In our study, we found that glyfoline ... WebGlyfoline (4,1,6-dihydroxy-10-methyl-2,3,4,5-tetramethoxyacridin-9-one) and its congeners were synthesized for evaluation of their cytotoxicity. A detailed structure-activity relationships (SAR) of these acridone derivatives were also studied. To study the SAR of glyfoline analogues, substituent(s) at C-1 and C-6 and at the heterocyclic ...
Glyfoline
Did you know?
WebNov 1, 2007 · Abstract. A39 Glyfoline is an antineoplastic 9-acridone alkaloid isolated from Glycosmis citrifolia. Previous studies revealed that this natural product exhibited potent antitumor activity in mice bearing murine and human solid tumors. It also demonstrated that this alkaloid arrested human nasopharyngeal carcinoma cell cycle progression at the … WebMar 1, 2000 · Europe PMC is an archive of life sciences journal literature.
WebThe world's first wiki where authorship really matters. Due credit and reputation for authors [authorship tracking technology]. Imagine a global collaborative knowledge base for original thoughts [Nature Genetics]. WebFeb 1, 2005 · Glyfoline induced the appearance of spindle abnormalities, chromosome mis-segregation, multipolar cell division and multiple nuclei, all of which are indicative of …
Webglyfoline Preferred. page delivered in 0.004s Connect with NLM National Library of Medicine 8600 Rockville Pike Bethesda, MD 20894 Web Policies FOIA HHS Vulnerability Disclosure NLM Support Center ... WebGet to learn about glyfoline. The overall knowledge and encyclopedia of glyfoline covering characteristics, safety, usage, MSDS/SDS and more.
WebApr 14, 2004 · Additionally, our current studies revealed that glyfoline induced apoptotic changes and arrested cell cycle procession at the G2/M phase in nasopharyngeal carcinoma (NPC). A reverse transcriptase polymerase chain reaction (RT-PCR) showed no specific changes of apoptosis-related gene expression (i. e., bax, ICE-α,β, bcl-2, and c-myc). …
WebFeb 17, 2024 · Synthesis, characterization, crystal structures, and the biological evaluation of 2-phenylthiazole derivatives as cholinesterase inhibitors Da-Hua Shi and more ... Journal of Chemical Research Dec 2024 SAGE recommends: SAGE Knowledge Book chapter DNA and the Genetic Code Gregory Carey Human Genetics for the Social Sciences 2003 … marshmallow strawberry plantsWebDec 30, 2024 · Common side effects of dyphylline and guaifenesin may include: nausea, vomiting, stomach pain, diarrhea; headache; feeling restless or irritable; sleep problems ( … marshmallow strawberry plants ukWebDec 28, 1999 · Antineoplastic glyfoline ( 1) has potent antitumor efficacy against various murine and human solid tumors. To elucidate the actual mechanism of action, we … marshmallow strawberryWebMar 18, 1991 · Condensation of 4-benzyloxy-3-methoxyanthranilic acid (3) with 5-iodo-1,2,3,4-tetramethoxybenzene (4) gave 6-benzyloxy-1,2,3,4,5-pentamethoxy-9-acridone … marshmallow stuffed animal owlmarshmallow study radiologyWebglyfoline congeners by Watanabe and Su revealed that the intramolecular hydrogen bonding between the 1-hydroxy and the peri-carbonyl function of the 1- hydroxy-9-acridone nucleus was an important deter- minant of their cytotoxicity (Chou et aL, 1989 and Su et al., 1989). A positive inductive effect on this hydro- ... marshmallow stuffed animalsWebJan 1, 1997 · Among 50 alkaloids tested, glyfoline (2) was found to be the most active compound (IC50 = 2.2 wM) and 22 alkaloids were found to be more active than acronycine. marshmallow stuffed toys